| 16. Round | 14/11/1980 | SpVgg Fürth | - | VfB Eppingen | 2:1 | ||||
| 17. Round | 27/11/1980 | VfB Eppingen | - | 1. FC Saarbrücken | 4:0 | ||||
| 19. Round | 12/12/1980 | VfB Eppingen | - | Wormatia Worms | 2:0 | ||||
| 21. Round | 09/01/1981 | SV Darmstadt 98 | - | VfB Eppingen | 2:0 | ||||
| 23. Round | 23/01/1981 | Hessen Kassel | - | VfB Eppingen | 3:1 |  |
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| 20. Round | 27/02/1981 | VfB Eppingen | - | FSV Frankfurt | 5:1 | |
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| 27. Round | 05/03/1981 | VfB Eppingen | - | Borussia Neunkirchen | 2:2 | |
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| 28. Round | 12/03/1981 | VfR Bürstadt | - | VfB Eppingen | 2:1 | |
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| 29. Round | 20/03/1981 | VfB Eppingen | - | Stuttgarter Kickers | 1:0 | ||||
| 30. Round | 26/03/1981 | ESV Ingolstadt | - | VfB Eppingen | 3:1 | ||||
| 24. Round | 30/03/1981 | VfB Eppingen | - | FC Augsburg | 1:1 | |
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| 32. Round | 09/04/1981 | Freiburger FC | - | VfB Eppingen | 2:1 | ||||
| 33. Round | 14/04/1981 | VfB Eppingen | - | SSV Ulm 1846 | 0:0 | ||||
| 34. Round | 23/04/1981 | SpVgg Bayreuth | - | VfB Eppingen | 0:0 | ||||
| 35. Round | 29/04/1981 | VfB Eppingen | - | SpVgg Fürth | 1:2 | ||||
| 36. Round | 07/05/1981 | 1. FC Saarbrücken | - | VfB Eppingen | 1:0 | ||||
| 37. Round | 14/05/1981 | VfB Eppingen | - | FC 08 Homburg | 0:5 |
Germany