| 22. Round | 22/01/2022 | Würzburger Kickers | - | Waldhof Mannheim | 1:2 |  |
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| 23. Round | 25/01/2022 | VfL Osnabrück | - | Würzburger Kickers | 2:0 | |
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| 24. Round | 28/01/2022 | Würzburger Kickers | - | SC Freiburg II | 1:1 | ||||
| 25. Round | 07/02/2022 | 1. FC Saarbrücken | - | Würzburger Kickers | 2:1 |  |
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| 28. Round | 26/02/2022 | Würzburger Kickers | - | 1. FC Magdeburg | 2:4 | |
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| 31. Round | 18/03/2022 | Würzburger Kickers | - | Viktoria Köln | 0:1 | ||||
| 33. Round | 08/04/2022 | Würzburger Kickers | - | 1. FC Kaiserslautern | 1:2 | ||||
| 34. Round | 16/04/2022 | Eintracht Braunschweig | - | Würzburger Kickers | 1:0 | ||||
| 35. Round | 23/04/2022 | Würzburger Kickers | - | FC Viktoria 1889 Berlin | 3:0 | ||||
| 36. Round | 30/04/2022 | SV Meppen | - | Würzburger Kickers | 2:4 | ||||
| 37. Round | 08/05/2022 | Würzburger Kickers | - | Hallescher FC | 1:2 |  |
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| 38. Round | 14/05/2022 | FSV Zwickau | - | Würzburger Kickers | 7:0 |
Germany