| 1. Round | 04/08/1980 | 1. FC Saarbrücken | - | VfR Bürstadt | 0:2 | ||||
| 2. Round | 08/08/1980 | VfR Bürstadt | - | FC 08 Homburg | 3:1 | ||||
| 3. Round | 15/08/1980 | Wormatia Worms | - | VfR Bürstadt | 1:2 | ||||
| 4. Round | 19/08/1980 | VfR Bürstadt | - | FSV Frankfurt | 0:1 | ||||
| 5. Round | 22/08/1980 | SV Darmstadt 98 | - | VfR Bürstadt | 5:0 | ||||
| 6. Round | 28/08/1980 | VfR Bürstadt | - | SC Freiburg | 1:1 | ||||
| 7. Round | 04/09/1980 | Hessen Kassel | - | VfR Bürstadt | 4:0 |  |
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| 8. Round | 11/09/1980 | VfR Bürstadt | - | FC Augsburg | 2:0 | ||||
| 9. Round | 19/09/1980 | VfB Eppingen | - | VfR Bürstadt | 2:1 | ||||
| 10. Round | 25/09/1980 | VfR Bürstadt | - | Eintracht Trier | 2:1 | |
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| 11. Round | 10/10/1980 | Borussia Neunkirchen | - | VfR Bürstadt | 0:0 | ||||
| 12. Round | 17/10/1980 | VfR Bürstadt | - | Waldhof Mannheim | 0:1 | |
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| 13. Round | 25/10/1980 | VfR Bürstadt | - | Stuttgarter Kickers | 3:2 |  |
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| 14. Round | 30/10/1980 | ESV Ingolstadt | - | VfR Bürstadt | 4:1 | ||||
| 15. Round | 07/11/1980 | VfR Bürstadt | - | Kickers Offenbach | 2:2 | ||||
| 16. Round | 14/11/1980 | Freiburger FC | - | VfR Bürstadt | 3:2 | ||||
| 17. Round | 27/11/1980 | VfR Bürstadt | - | SSV Ulm 1846 | 1:4 |
Germany