| 1. Round | 27/07/2024 | SC Wiedenbrück | - | FC Schalke 04 II | 0:2 |  |
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| 2. Round | 03/08/2024 | FC Schalke 04 II | - | KFC Uerdingen 05 | annull. | ||||
| 3. Round | 09/08/2024 | FC Schalke 04 II | - | SV Rödinghausen | 2:2 | ||||
| 5. Round | 24/08/2024 | FC Schalke 04 II | - | 1. FC Düren | 1:4 | ||||
| 9. Round | 28/09/2024 | FC Schalke 04 II | - | MSV Duisburg | 1:2 | ||||
| 13. Round | 25/10/2024 | FC Schalke 04 II | - | Rot-Weiß Oberhausen | 1:2 | ||||
| 14. Round | 02/11/2024 | Eintracht Hohkeppel | - | FC Schalke 04 II | 2:1 |  |
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| 15. Round | 08/11/2024 | FC Schalke 04 II | - | SC Paderborn 07 II | 0:4 | |
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| 17. Round | 30/11/2024 | FC Schalke 04 II | - | Fortuna Köln | 0:1 | ||||
| 18. Round | 07/12/2024 | FC Schalke 04 II | - | SC Wiedenbrück | 3:1 | ||||
| 20. Round | 01/02/2025 | SV Rödinghausen | - | FC Schalke 04 II | 0:0 | ||||
| 21. Round | 08/02/2025 | FC Schalke 04 II | - | 1. FC Bocholt | 0:0 | ||||
| 27. Round | 29/03/2025 | FC Schalke 04 II | - | Sportfreunde Lotte | 1:2 | ||||
| 28. Round | 05/04/2025 | FC Gütersloh | - | FC Schalke 04 II | 3:2 | ||||
| 30. Round | 19/04/2025 | Rot-Weiß Oberhausen | - | FC Schalke 04 II | 0:3 | |
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| 31. Round | 26/04/2025 | FC Schalke 04 II | - | Eintracht Hohkeppel | 5:0 |
Germany