| 5. Round | 26/09/2021 | SpVgg Vreden | - | SC Paderborn 07 II | 0:5 | ||||
| 6. Round | 03/10/2021 | SC Paderborn 07 II | - | FC Gütersloh | 1:1 | ||||
| 7. Round | 10/10/2021 | TuS Haltern | - | SC Paderborn 07 II | 2:5 |  |
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| 8. Round | 17/10/2021 | SC Paderborn 07 II | - | TuS Erndtebrück | 5:0 | ||||
| 14. Round | 25/11/2021 | Holzwickeder SC | - | SC Paderborn 07 II | 0:6 | ||||
| 15. Round | 05/12/2021 | SC Paderborn 07 II | - | ASC 09 Dortmund | 3:1 | ||||
| 11. Round | 08/12/2021 | SC Paderborn 07 II | - | RSV Meinerzhagen | 5:1 | ||||
| 16. Round | 12/12/2021 | SG Finnentrop/Bamenohl | - | SC Paderborn 07 II | 2:2 | ||||
| 17. Round | 20/02/2022 | SC Paderborn 07 II | - | 1. FC Kaan-Marienborn | 1:1 | ||||
| 18. Round | 06/03/2022 | Viktoria Clarholz | - | SC Paderborn 07 II | 2:2 | ||||
| 19. Round | 13/03/2022 | SC Paderborn 07 II | - | TuS Ennepetal | 2:0 | ||||
| 21. Round | 26/03/2022 | SC Paderborn 07 II | - | SG Wattenscheid 09 | 3:0 | ||||
| 20. Round | 30/03/2022 | SV Schermbeck | - | SC Paderborn 07 II | 1:2 | |
Ghana