| 1. Round | 05/08/2022 | MSV 1919 Neuruppin | - | FC Mecklenburg Schwerin | 3:0 | ||||
| 2. Round | 14/08/2022 | FC Mecklenburg Schwerin | - | 1. FC Frankfurt (Oder) | 0:7 | ||||
| 3. Round | 20/08/2022 | Rostocker FC | - | FC Mecklenburg Schwerin | 6:1 | ||||
| 4. Round | 26/08/2022 | FC Mecklenburg Schwerin | - | MSV Pampow | 0:2 |  |
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| 7. Round | 02/10/2022 | TSG Neustrelitz | - | FC Mecklenburg Schwerin | 4:1 | ||||
| 8. Round | 08/10/2022 | FC Mecklenburg Schwerin | - | Eintracht Mahlsdorf | 1:2 | ||||
| 9. Round | 16/10/2022 | Hansa Rostock II | - | FC Mecklenburg Schwerin | 3:0 | ||||
| 10. Round | 22/10/2022 | FC Mecklenburg Schwerin | - | Blau-Weiß 90 Berlin | 3:3 |  |
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| 11. Round | 30/10/2022 | FC Mecklenburg Schwerin | - | CFC Hertha 06 | 0:1 |
Germany