| 1. Round | 15/08/2021 | FC Carl Zeiss Jena [Youth] | - | VfL Osnabrück [Youth] | 0:0 | ||||
| 3. Round | 12/09/2021 | VfL Osnabrück [Youth] | - | Holstein Kiel [Youth] | 0:2 | ||||
| 4. Round | 19/09/2021 | RB Leipzig [Youth] | - | VfL Osnabrück [Youth] | 4:0 |  |
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| 5. Round | 26/09/2021 | VfL Osnabrück [Youth] | - | Chemnitzer FC [Youth] | 1:0 | ||||
| 6. Round | 03/10/2021 | Eimsbütteler TV [Youth] | - | VfL Osnabrück [Youth] | 2:1 |  |
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| 13. Round | 20/02/2022 | VfL Osnabrück [Youth] | - | 1. FC Magdeburg [Youth] | 2:2 | ||||
| 16. Round | 03/04/2022 | Hansa Rostock [Youth] | - | VfL Osnabrück [Youth] | 0:1 | ||||
| 17. Round | 09/04/2022 | VfL Osnabrück [Youth] | - | Energie Cottbus [Youth] | 2:0 | |
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| 18. Round | 23/04/2022 | Hamburger SV [Youth] | - | VfL Osnabrück [Youth] | 4:1 | ||||
| 19. Round | 30/04/2022 | VfL Osnabrück [Youth] | - | FC St. Pauli [Youth] | 1:9 |
Germany