| 1. Round | 29/08/2021 | 1. FC Kaan-Marienborn | - | ASC 09 Dortmund | 3:1 | ||||
| 2. Round | 05/09/2021 | ASC 09 Dortmund | - | Viktoria Clarholz | 5:2 |  |
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| 3. Round | 12/09/2021 | TuS Ennepetal | - | ASC 09 Dortmund | 2:3 | |
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| 4. Round | 19/09/2021 | ASC 09 Dortmund | - | SV Schermbeck | 2:2 | ||||
| 7. Round | 10/10/2021 | TSG Sprockhövel | - | ASC 09 Dortmund | 3:3 | ||||
| 8. Round | 17/10/2021 | ASC 09 Dortmund | - | Hammer SpVg | 3:0 | ||||
| 9. Round | 24/10/2021 | Sportfreunde Siegen | - | ASC 09 Dortmund | 1:1 | ||||
| 15. Round | 05/12/2021 | SC Paderborn 07 II | - | ASC 09 Dortmund | 3:1 | ||||
| 17. Round | 27/02/2022 | Westfalia Herne | - | ASC 09 Dortmund | 2:4 | ||||
| 18. Round | 06/03/2022 | ASC 09 Dortmund | - | Westfalia Rhynern | 1:2 | ||||
| 21. Round | 27/03/2022 | ASC 09 Dortmund | - | SG Finnentrop/Bamenohl | 2:2 |
Germany