| 3. Round | 09/08/2022 | FSV Zwickau | - | MSV Duisburg | 0:1 | ||||
| 4. Round | 15/08/2022 | MSV Duisburg | - | SC Freiburg II | 3:1 | ||||
| 5. Round | 21/08/2022 | SV Meppen | - | MSV Duisburg | 0:3 | ||||
| 7. Round | 03/09/2022 | TSV 1860 München | - | MSV Duisburg | 4:1 | ||||
| 8. Round | 11/09/2022 | MSV Duisburg | - | Dynamo Dresden | 0:1 | ||||
| 10. Round | 01/10/2022 | MSV Duisburg | - | Hallescher FC | 1:0 | ||||
| 11. Round | 08/10/2022 | SV 07 Elversberg | - | MSV Duisburg | 3:0 | ||||
| 12. Round | 16/10/2022 | Borussia Dortmund II | - | MSV Duisburg | 2:0 | ||||
| 14. Round | 28/10/2022 | SV Wehen Wiesbaden | - | MSV Duisburg | 1:3 | ||||
| 16. Round | 08/11/2022 | Erzgebirge Aue | - | MSV Duisburg | 0:2 | ||||
| 17. Round | 12/11/2022 | MSV Duisburg | - | FC Ingolstadt 04 | 0:1 |  |
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| 18. Round | 14/01/2023 | 1. FC Saarbrücken | - | MSV Duisburg | 2:3 | |
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| 21. Round | 05/02/2023 | Rot-Weiss Essen | - | MSV Duisburg | 1:1 | ||||
| 26. Round | 11/03/2023 | MSV Duisburg | - | TSV 1860 München | 2:2 | ||||
| 27. Round | 15/03/2023 | Dynamo Dresden | - | MSV Duisburg | 2:0 | ||||
| 28. Round | 18/03/2023 | MSV Duisburg | - | SC Verl | 3:3 | ||||
| 29. Round | 24/03/2023 | Hallescher FC | - | MSV Duisburg | 2:2 | ||||
| 31. Round | 08/04/2023 | MSV Duisburg | - | Borussia Dortmund II | 0:5 |
Germany