| 2. Round | 20/08/2022 | MSV Duisburg [Youth B] | - | 1. FC Köln [Youth B] | 2:1 | ||||
| 3. Round | 27/08/2022 | 1. FC Köln [Youth B] | - | Preußen Münster [Youth B] | 3:1 | ||||
| 4. Round | 03/09/2022 | Borussia Dortmund [Youth B] | - | 1. FC Köln [Youth B] | 3:3 | ||||
| 5. Round | 11/09/2022 | 1. FC Köln [Youth B] | - | SC Paderborn 07 [Youth B] | 5:1 | ||||
| 6. Round | 17/09/2022 | Sportfreunde Siegen [Youth B] | - | 1. FC Köln [Youth B] | 2:4 | ||||
| 7. Round | 01/10/2022 | 1. FC Köln [Youth B] | - | Rot-Weiss Essen [Youth B] | 5:1 | ||||
| 8. Round | 09/10/2022 | Fortuna Düsseldorf [Youth B] | - | 1. FC Köln [Youth B] | 1:2 |  |
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| 9. Round | 28/10/2022 | 1. FC Köln [Youth B] | - | FC Hennef 05 [Youth B] | 3:0 | ||||
| 11. Round | 12/11/2022 | 1. FC Köln [Youth B] | - | Bayer Leverkusen [Youth B] | 2:4 |
Germany