| 20. Round | 20/02/2016 | SV Oberachern | - | Karlsruher SC II | 2:2 | ||||
| 21. Round | 28/02/2016 | Karlsruher SC II | - | SV Sandhausen II | 2:1 | ||||
| 22. Round | 05/03/2016 | FSV Hollenbach | - | Karlsruher SC II | 1:3 |  |
 |
||
| 23. Round | 12/03/2016 | Karlsruher SC II | - | Freiburger FC | 3:0 | ||||
| 24. Round | 19/03/2016 | FC 08 Villingen | - | Karlsruher SC II | 1:0 | ||||
| 25. Round | 26/03/2016 | Karlsruher SC II | - | SGV Freiberg | 0:1 | ||||
| 26. Round | 02/04/2016 | SC Pfullendorf | - | Karlsruher SC II | 0:3 | |
|
||
| 27. Round | 10/04/2016 | Karlsruher SC II | - | FC Nöttingen | 4:1 | |
|||
| 28. Round | 17/04/2016 | Stuttgarter Kickers II | - | Karlsruher SC II | 1:0 | ||||
| 30. Round | 01/05/2016 | FC Germania Friedrichstal | - | Karlsruher SC II | 2:3 | ||||
| 31. Round | 08/05/2016 | Karlsruher SC II | - | SSV Ulm 1846 | 1:0 | |
|||
| 32. Round | 11/05/2016 | Karlsruher SC II | - | SSV Reutlingen | 1:2 | ||||
| 33. Round | 14/05/2016 | FSV 08 Bissingen | - | Karlsruher SC II | 2:0 |
Germany