| 1. Round | 22/08/2021 | TV Jahn Hiesfeld | - | FC Kray | 1:4 | ||||
| 2. Round | 29/08/2021 | DJK Teutonia St. Tönis | - | TV Jahn Hiesfeld | 4:1 | ||||
| 3. Round | 05/09/2021 | TV Jahn Hiesfeld | - | TuRU Düsseldorf | 1:2 | ||||
| 6. Round | 26/09/2021 | 1. FC Mönchengladbach | - | TV Jahn Hiesfeld | 0:8 |  |
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| 8. Round | 10/10/2021 | VfB 03 Hilden | - | TV Jahn Hiesfeld | 1:0 | ||||
| 9. Round | 17/10/2021 | TV Jahn Hiesfeld | - | SC Velbert | 2:1 | ||||
| 12. Round | 07/11/2021 | TV Jahn Hiesfeld | - | SpVg Schonnebeck | 0:3 | ||||
| 13. Round | 14/11/2021 | Cronenberger SC | - | TV Jahn Hiesfeld | 2:0 | ||||
| 14. Round | 28/11/2021 | TV Jahn Hiesfeld | - | SC Union Nettetal | 1:3 |  |
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| 16. Round | 12/12/2021 | TV Jahn Hiesfeld | - | Sportfreunde Baumberg | 2:3 | ||||
| 17. Round | 18/12/2021 | 1. FC Kleve | - | TV Jahn Hiesfeld | 5:1 | ||||
| 19. Round | 27/02/2022 | 1. FC Bocholt | - | TV Jahn Hiesfeld | 3:0 | ||||
| 20. Round | 06/03/2022 | TV Jahn Hiesfeld | - | SSVg Velbert | 1:0 | ||||
| 21. Round | 13/03/2022 | TVD Velbert | - | TV Jahn Hiesfeld | 4:0 |
Germany