| 1. Round | 22/08/2021 | SC Velbert | - | TuRU Düsseldorf | 4:1 |  |
 |
||
| 2. Round | 29/08/2021 | Germania Ratingen 04/19 | - | SC Velbert | 2:0 | ||||
| 3. Round | 04/09/2021 | SC Velbert | - | 1. FC Monheim | 1:1 | ||||
| 5. Round | 18/09/2021 | SC Velbert | - | FSV Duisburg | 2:0 | ||||
| 10. Round | 24/10/2021 | SC Velbert | - | SpVg Schonnebeck | 1:3 | ||||
| 14. Round | 27/11/2021 | SC Velbert | - | Sportfreunde Baumberg | 0:3 | ||||
| 15. Round | 03/12/2021 | 1. FC Kleve | - | SC Velbert | 8:0 | ||||
| 16. Round | 11/12/2021 | SC Velbert | - | TSV Meerbusch | 2:3 | ||||
| 17. Round | 18/12/2021 | 1. FC Bocholt | - | SC Velbert | 5:0 | |
|||
| 19. Round | 26/02/2022 | TVD Velbert | - | SC Velbert | 2:0 | |
|||
| 20. Round | 06/03/2022 | SC Velbert | - | SpVgg Sterkrade-Nord | 3:1 |  |
|||
| 18. Round | 16/03/2022 | SC Velbert | - | SSVg Velbert | 0:5 | ||||
| 23. Round | 27/03/2022 | DJK Teutonia St. Tönis | - | SC Velbert | 0:0 | ||||
| 22. Round | 30/03/2022 | SC Velbert | - | FC Kray | 2:4 | |
Germany