| 10. Round | 25/09/1980 | SpVgg Bayreuth | - | FSV Frankfurt | 0:1 | ||||
| 12. Round | 17/10/1980 | 1. FC Saarbrücken | - | FSV Frankfurt | 3:1 | ||||
| 13. Round | 25/10/1980 | FSV Frankfurt | - | FC 08 Homburg | 0:2 | ||||
| 15. Round | 07/11/1980 | Waldhof Mannheim | - | FSV Frankfurt | 1:0 | ||||
| 17. Round | 27/11/1980 | SC Freiburg | - | FSV Frankfurt | 2:1 |  |
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| 18. Round | 05/12/1980 | FSV Frankfurt | - | Hessen Kassel | 1:0 | ||||
| 19. Round | 12/12/1980 | FC Augsburg | - | FSV Frankfurt | 2:2 | ||||
| 23. Round | 23/01/1981 | FSV Frankfurt | - | VfR Bürstadt | 1:4 | ||||
| 25. Round | 13/02/1981 | FSV Frankfurt | - | ESV Ingolstadt | 1:3 | ||||
| 22. Round | 21/02/1981 | Borussia Neunkirchen | - | FSV Frankfurt | 2:1 | ||||
| 20. Round | 27/02/1981 | VfB Eppingen | - | FSV Frankfurt | 5:1 | ||||
| 27. Round | 05/03/1981 | FSV Frankfurt | - | Freiburger FC | 2:6 | ||||
| 30. Round | 26/03/1981 | SpVgg Fürth | - | FSV Frankfurt | 2:0 | ||||
| 31. Round | 03/04/1981 | FSV Frankfurt | - | 1. FC Saarbrücken | 3:0 | ||||
| 32. Round | 09/04/1981 | FC 08 Homburg | - | FSV Frankfurt | 5:1 |
Germany