| 1. Round | 29/08/2021 | Hammer SpVg | - | TuS Erndtebrück | 4:0 | ||||
| 2. Round | 05/09/2021 | TuS Erndtebrück | - | Sportfreunde Siegen | 3:3 |  |
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| 3. Round | 12/09/2021 | SpVgg Vreden | - | TuS Erndtebrück | 1:1 | ||||
| 4. Round | 19/09/2021 | TuS Erndtebrück | - | FC Gütersloh | 3:0 | |
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| 11. Round | 07/11/2021 | TuS Erndtebrück | - | Westfalia Rhynern | 1:4 | ||||
| 12. Round | 14/11/2021 | Holzwickeder SC | - | TuS Erndtebrück | 0:6 | ||||
| 13. Round | 20/11/2021 | TuS Erndtebrück | - | ASC 09 Dortmund | 0:1 | ||||
| 14. Round | 28/11/2021 | SG Finnentrop/Bamenohl | - | TuS Erndtebrück | 3:4 | |
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| 16. Round | 12/12/2021 | Viktoria Clarholz | - | TuS Erndtebrück | 2:2 |  |
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| 17. Round | 20/02/2022 | TuS Erndtebrück | - | TuS Ennepetal | 3:2 |
Germany