| 1. Round | 13/08/1977 | BFC Dynamo | - | HFC Chemie | 2:2 | ||||
| 2. Round | 20/08/1977 | HFC Chemie | - | FC Carl Zeiss Jena | 1:2 | ||||
| 4. Round | 03/09/1977 | HFC Chemie | - | BSG Wismut Aue | 6:0 |  |
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| 5. Round | 10/09/1977 | BSG Sachsenring Zwickau | - | HFC Chemie | 2:3 |  |
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| 6. Round | 01/10/1977 | FC Vorwärts Frankfurt/Oder | - | HFC Chemie | 0:0 | ||||
| 7. Round | 04/10/1977 | HFC Chemie | - | 1. FC Lokomotive Leipzig | 1:0 | |
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| 8. Round | 15/10/1977 | 1. FC Union Berlin | - | HFC Chemie | 1:1 | ||||
| 9. Round | 04/11/1977 | HFC Chemie | - | Rot-Weiß Erfurt | 3:0 | ||||
| 13. Round | 16/12/1977 | HFC Chemie | - | BSG Chemie Böhlen | 4:0 | ||||
| 14. Round | 17/02/1978 | HFC Chemie | - | BFC Dynamo | 0:0 | ||||
| 15. Round | 23/02/1978 | FC Carl Zeiss Jena | - | HFC Chemie | 6:1 | ||||
| 19. Round | 08/04/1978 | HFC Chemie | - | FC Vorwärts Frankfurt/Oder | 2:2 | ||||
| 21. Round | 22/04/1978 | HFC Chemie | - | 1. FC Union Berlin | 1:2 | ||||
| 24. Round | 20/05/1978 | BSG Wismut Gera | - | HFC Chemie | 0:1 | ||||
| 26. Round | 03/06/1978 | BSG Chemie Böhlen | - | HFC Chemie | 5:3 |
Germany