| 1. Round | 04/08/1980 | Waldhof Mannheim | - | Freiburger FC | 5:0 | ||||
| 2. Round | 08/08/1980 | Freiburger FC | - | SSV Ulm 1846 | 0:1 | ||||
| 3. Round | 15/08/1980 | SpVgg Bayreuth | - | Freiburger FC | 5:1 | ||||
| 4. Round | 19/08/1980 | Freiburger FC | - | SpVgg Fürth | 2:0 |  |
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| 5. Round | 22/08/1980 | 1. FC Saarbrücken | - | Freiburger FC | 2:2 | ||||
| 6. Round | 28/08/1980 | Freiburger FC | - | FC 08 Homburg | 7:3 | ||||
| 7. Round | 04/09/1980 | Wormatia Worms | - | Freiburger FC | 1:3 | ||||
| 8. Round | 11/09/1980 | Freiburger FC | - | FSV Frankfurt | 1:1 | ||||
| 18. Round | 19/12/1980 | Freiburger FC | - | ESV Ingolstadt | 2:2 | |
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| 23. Round | 23/01/1981 | SpVgg Fürth | - | Freiburger FC | 1:1 | ||||
| 27. Round | 05/03/1981 | FSV Frankfurt | - | Freiburger FC | 2:6 | |
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| 28. Round | 12/03/1981 | Freiburger FC | - | SV Darmstadt 98 | 2:0 | ||||
| 29. Round | 20/03/1981 | SC Freiburg | - | Freiburger FC | 0:0 | ||||
| 30. Round | 26/03/1981 | Freiburger FC | - | Hessen Kassel | 0:3 |
Germany