| 5. Round | 04/10/1980 | BSG Chemie Leipzig | - | BSG Chemie Buna Schkopau | 3:1 | ||||
| 6. Round | 07/10/1980 | BSG Lokomotive Stendal | - | BSG Chemie Leipzig | 1:1 | ||||
| 7. Round | 18/10/1980 | BSG Chemie Leipzig | - | BSG Chemie Zeitz | 1:0 | ||||
| 8. Round | 26/10/1980 | BSG Stahl Blankenburg | - | BSG Chemie Leipzig | 1:1 | ||||
| 9. Round | 08/11/1980 | BSG Chemie Leipzig | - | BSG MK Sangerhausen | 1:0 | ||||
| 10. Round | 15/11/1980 | Chemie Schönebeck | - | BSG Chemie Leipzig | 1:3 | ||||
| 11. Round | 22/11/1980 | BSG Chemie Leipzig | - | BSG Stahl Nordwest Leipzig | 4:3 | ||||
| 12. Round | 29/11/1980 | BSG Chemie Leipzig | - | ASG Vorwärts Dessau | 1:3 | ||||
| 13. Round | 06/12/1980 | BSG Chemie Wolfen | - | BSG Chemie Leipzig | 2:2 |  |
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| 14. Round | 12/12/1980 | BSG Stahl Thale | - | BSG Chemie Leipzig | 0:1 | ||||
| 15. Round | 28/02/1981 | SG Dynamo Eisleben | - | BSG Chemie Leipzig | 0:1 | ||||
| 16. Round | 07/03/1981 | BSG Chemie Buna Schkopau | - | BSG Chemie Leipzig | 3:2 | ||||
| 17. Round | 13/03/1981 | BSG Chemie Leipzig | - | BSG Lokomotive Stendal | 1:1 | ||||
| 18. Round | 21/03/1981 | BSG Chemie Zeitz | - | BSG Chemie Leipzig | 1:1 | ||||
| 19. Round | 28/03/1981 | BSG Chemie Leipzig | - | BSG Stahl Blankenburg | 1:3 |
Germany