| 1. Round | 22/08/2021 | SC Velbert | - | TuRU Düsseldorf | 4:1 | ||||
| 2. Round | 29/08/2021 | TuRU Düsseldorf | - | Sportfreunde Niederwenigern | 2:2 | ||||
| 3. Round | 05/09/2021 | TV Jahn Hiesfeld | - | TuRU Düsseldorf | 1:2 | ||||
| 4. Round | 12/09/2021 | TuRU Düsseldorf | - | SpVg Schonnebeck | 3:3 |  |
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| 5. Round | 19/09/2021 | Cronenberger SC | - | TuRU Düsseldorf | 0:3 | ||||
| 7. Round | 03/10/2021 | SC Düsseldorf-West | - | TuRU Düsseldorf | 0:1 | ||||
| 8. Round | 10/10/2021 | TuRU Düsseldorf | - | Sportfreunde Baumberg | 2:0 |  |
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| 9. Round | 17/10/2021 | 1. FC Kleve | - | TuRU Düsseldorf | 2:1 | ||||
| 10. Round | 24/10/2021 | TuRU Düsseldorf | - | TSV Meerbusch | 0:1 | ||||
| 11. Round | 31/10/2021 | 1. FC Bocholt | - | TuRU Düsseldorf | 4:0 | |
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| 12. Round | 05/11/2021 | TuRU Düsseldorf | - | SSVg Velbert | 1:4 | ||||
| 13. Round | 14/11/2021 | TVD Velbert | - | TuRU Düsseldorf | 4:2 | ||||
| 20. Round | 06/03/2022 | 1. FC Monheim | - | TuRU Düsseldorf | 0:2 | ||||
| 21. Round | 13/03/2022 | TuRU Düsseldorf | - | 1. FC Mönchengladbach | 2:2 |
North Macedonia