| 16. Round | 14/02/2016 | 1. FSV Mainz 05 [Youth B] | - | 1899 Hoffenheim [Youth B] | 3:1 |  |
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| 17. Round | 20/02/2016 | 1899 Hoffenheim [Youth B] | - | Karlsruher SC [Youth B] | 6:0 | ||||
| 18. Round | 28/02/2016 | Bayern München [Youth B] | - | 1899 Hoffenheim [Youth B] | 5:2 | |
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| 19. Round | 05/03/2016 | 1899 Hoffenheim [Youth B] | - | 1. FC Kaiserslautern [Youth B] | 3:1 | ||||
| 21. Round | 19/03/2016 | 1899 Hoffenheim [Youth B] | - | VfB Stuttgart [Youth B] | 0:1 | |
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| 22. Round | 09/04/2016 | SV 07 Elversberg [Youth B] | - | 1899 Hoffenheim [Youth B] | 1:0 | ||||
| 24. Round | 23/04/2016 | FC Augsburg [Youth B] | - | 1899 Hoffenheim [Youth B] | 3:2 | ||||
| 25. Round | 28/05/2016 | 1899 Hoffenheim [Youth B] | - | TSV 1860 München [Youth B] | 2:1 |
Germany