| 1. Round | 15/08/2021 | VfL Wolfsburg II [Women] | - | RB Leipzig [Women] | 1:2 | ||||
| 2. Round | 29/08/2021 | RB Leipzig [Women] | - | 1899 Hoffenheim II [Women] | 2:0 | ||||
| 3. Round | 05/09/2021 | Bayern München II [Women] | - | RB Leipzig [Women] | 3:1 | ||||
| 4. Round | 12/09/2021 | RB Leipzig [Women] | - | Eintracht Frankfurt II [Women] | 4:0 |  |
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| 5. Round | 03/10/2021 | SV Meppen [Women] | - | RB Leipzig [Women] | 5:0 | ||||
| 12. Round | 12/12/2021 | FSV Gütersloh 2009 [Women] | - | RB Leipzig [Women] | 1:4 | ||||
| 9. Round | 15/12/2021 | FC Ingolstadt 04 [Women] | - | RB Leipzig [Women] | 2:3 | ||||
| 13. Round | 19/12/2021 | RB Leipzig [Women] | - | MSV Duisburg [Women] | 3:0 | ||||
| 18. Round | 27/03/2022 | RB Leipzig [Women] | - | SV Meppen [Women] | 4:2 | ||||
| 25. Round | 22/05/2022 | RB Leipzig [Women] | - | FSV Gütersloh 2009 [Women] | 6:1 |
Germany