1. Round | 14/08/2021 | FC Augsburg | - | 1899 Hoffenheim | 0:4 | ||||
2. Round | 22/08/2021 | 1899 Hoffenheim | - | 1. FC Union Berlin | 2:2 | ||||
3. Round | 27/08/2021 | Borussia Dortmund | - | 1899 Hoffenheim | 3:2 | ||||
5. Round | 18/09/2021 | Arminia Bielefeld | - | 1899 Hoffenheim | 0:0 | ||||
6. Round | 25/09/2021 | 1899 Hoffenheim | - | VfL Wolfsburg | 3:1 | ||||
7. Round | 02/10/2021 | VfB Stuttgart | - | 1899 Hoffenheim | 3:1 | ||||
9. Round | 23/10/2021 | Bayern München | - | 1899 Hoffenheim | 4:0 | ||||
12. Round | 20/11/2021 | 1899 Hoffenheim | - | RB Leipzig | 2:0 | ||||
13. Round | 27/11/2021 | SpVgg Greuther Fürth | - | 1899 Hoffenheim | 3:6 | ||||
14. Round | 04/12/2021 | 1899 Hoffenheim | - | Eintracht Frankfurt | 3:2 | ||||
15. Round | 11/12/2021 | SC Freiburg | - | 1899 Hoffenheim | 1:2 | ||||
16. Round | 15/12/2021 | Bayer Leverkusen | - | 1899 Hoffenheim | 2:2 | ||||
18. Round | 08/01/2022 | 1899 Hoffenheim | - | FC Augsburg | 3:1 |