| 1. Round | 05/08/2005 | SV 07 Elversberg | - | Karlsruher SC II | 3:0 | ||||
| 2. Round | 13/08/2005 | Karlsruher SC II | - | TuS Koblenz | 0:2 | ||||
| 3. Round | 06/09/2005 | FC Augsburg | - | Karlsruher SC II | 1:0 | ||||
| 7. Round | 16/09/2005 | VfB Stuttgart II | - | Karlsruher SC II | 4:2 |  |
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| 9. Round | 24/09/2005 | Karlsruher SC II | - | 1. FC Kaiserslautern II | 3:1 | ||||
| 20. Round | 18/02/2006 | Karlsruher SC II | - | FC Augsburg | 2:2 | ||||
| 24. Round | 18/03/2006 | Karlsruher SC II | - | VfB Stuttgart II | 3:2 | ||||
| 25. Round | 24/03/2006 | SV Darmstadt 98 | - | Karlsruher SC II | 2:2 | ||||
| 26. Round | 02/04/2006 | 1. FC Kaiserslautern II | - | Karlsruher SC II | 1:0 | ||||
| 27. Round | 08/04/2006 | Karlsruher SC II | - | Eintracht Trier | 1:0 | ||||
| 21. Round | 19/04/2006 | SpVgg Bayreuth | - | Karlsruher SC II | 1:1 | ||||
| 30. Round | 28/04/2006 | VfR Aalen | - | Karlsruher SC II | 2:1 | ||||
| 22. Round | 02/05/2006 | Karlsruher SC II | - | 1. FC Eschborn | 0:0 | ||||
| 23. Round | 09/05/2006 | TSV 1860 München II | - | Karlsruher SC II | 2:0 | ||||
| 32. Round | 14/05/2006 | Bayern München II | - | Karlsruher SC II | 3:1 | ||||
| 33. Round | 20/05/2006 | Karlsruher SC II | - | Stuttgarter Kickers | 1:1 |
Germany