| 3. Round | 13/08/2021 | FC Schalke 04 | - | Erzgebirge Aue | 1:1 |  |
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| 4. Round | 22/08/2021 | Erzgebirge Aue | - | SV Sandhausen | 1:3 | ||||
| 5. Round | 28/08/2021 | Holstein Kiel | - | Erzgebirge Aue | 3:0 | ||||
| 6. Round | 12/09/2021 | Erzgebirge Aue | - | Fortuna Düsseldorf | 0:1 | ||||
| 7. Round | 19/09/2021 | Erzgebirge Aue | - | SC Paderborn 07 | 1:4 | ||||
| 8. Round | 24/09/2021 | Jahn Regensburg | - | Erzgebirge Aue | 3:2 | ||||
| 10. Round | 16/10/2021 | Karlsruher SC | - | Erzgebirge Aue | 2:1 | ||||
| 14. Round | 20/11/2021 | Hansa Rostock | - | Erzgebirge Aue | 1:2 | ||||
| 16. Round | 03/12/2021 | Werder Bremen | - | Erzgebirge Aue | 4:0 | ||||
| 20. Round | 22/01/2022 | Erzgebirge Aue | - | FC Schalke 04 | 0:5 |
Germany