| 1. Round | 19/09/2020 | 1. FC Köln | - | 1899 Hoffenheim | 2:3 |  |
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| 2. Round | 26/09/2020 | Arminia Bielefeld | - | 1. FC Köln | 1:0 | ||||
| 3. Round | 03/10/2020 | 1. FC Köln | - | Bor. Mönchengladbach | 1:3 | ||||
| 4. Round | 18/10/2020 | 1. FC Köln | - | Eintracht Frankfurt | 1:1 | ||||
| 5. Round | 23/10/2020 | VfB Stuttgart | - | 1. FC Köln | 1:1 | |
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| 6. Round | 31/10/2020 | 1. FC Köln | - | Bayern München | 1:2 | ||||
| 7. Round | 06/11/2020 | Werder Bremen | - | 1. FC Köln | 1:1 | ||||
| 8. Round | 22/11/2020 | 1. FC Köln | - | 1. FC Union Berlin | 1:2 | ||||
| 10. Round | 05/12/2020 | 1. FC Köln | - | VfL Wolfsburg | 2:2 | ||||
| 12. Round | 16/12/2020 | 1. FC Köln | - | Bayer Leverkusen | 0:4 | ||||
| 27. Round | 03/04/2021 | VfL Wolfsburg | - | 1. FC Köln | 1:0 | ||||
| 28. Round | 11/04/2021 | 1. FC Köln | - | 1. FSV Mainz 05 | 2:3 | ||||
| 31. Round | 23/04/2021 | FC Augsburg | - | 1. FC Köln | 2:3 | ||||
| 32. Round | 09/05/2021 | 1. FC Köln | - | SC Freiburg | 1:4 | |
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| 33. Round | 15/05/2021 | Hertha BSC | - | 1. FC Köln | 0:0 | ||||
| 34. Round | 22/05/2021 | 1. FC Köln | - | FC Schalke 04 | 1:0 |
Sweden