| 1. Round | 23/07/2022 | 1. FC Saarbrücken | - | SC Verl | 1:0 | ||||
| 2. Round | 06/08/2022 | SV 07 Elversberg | - | 1. FC Saarbrücken | 0:2 | ||||
| 4. Round | 13/08/2022 | FC Ingolstadt 04 | - | 1. FC Saarbrücken | 0:0 | ||||
| 5. Round | 20/08/2022 | 1. FC Saarbrücken | - | Erzgebirge Aue | 0:0 | ||||
| 6. Round | 27/08/2022 | VfL Osnabrück | - | 1. FC Saarbrücken | 2:2 |  |
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| 7. Round | 05/09/2022 | 1. FC Saarbrücken | - | SV Wehen Wiesbaden | 2:2 | |
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| 8. Round | 10/09/2022 | SpVgg Bayreuth | - | 1. FC Saarbrücken | 0:6 | |
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| 9. Round | 19/09/2022 | Rot-Weiss Essen | - | 1. FC Saarbrücken | 1:0 | ||||
| 10. Round | 01/10/2022 | 1. FC Saarbrücken | - | SC Freiburg II | 2:2 | ||||
| 11. Round | 08/10/2022 | Waldhof Mannheim | - | 1. FC Saarbrücken | 1:0 | ||||
| 12. Round | 15/10/2022 | 1. FC Saarbrücken | - | FSV Zwickau | 3:2 | |
Germany