| 22. Round | 22/01/2022 | Alemannia Aachen | - | SV Lippstadt 08 | 3:0 |  |
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| 25. Round | 12/02/2022 | SC Wiedenbrück | - | Alemannia Aachen | 1:1 | ||||
| 19. Round | 16/02/2022 | Alemannia Aachen | - | VfB Homberg | 2:0 | ||||
| 27. Round | 26/02/2022 | Alemannia Aachen | - | Bonner SC | 0:0 | ||||
| 28. Round | 05/03/2022 | Bor. Mönchengladbach II | - | Alemannia Aachen | 3:2 | ||||
| 29. Round | 12/03/2022 | Alemannia Aachen | - | Sportfreunde Lotte | 1:0 | ||||
| 23. Round | 16/03/2022 | Rot-Weiß Oberhausen | - | Alemannia Aachen | 2:1 |  |
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| 30. Round | 19/03/2022 | FC Wegberg-Beeck | - | Alemannia Aachen | 0:2 | ||||
| 31. Round | 27/03/2022 | Alemannia Aachen | - | SV Rödinghausen | 0:1 | ||||
| 33. Round | 10/04/2022 | Alemannia Aachen | - | Rot-Weiss Essen | 1:1 | ||||
| 34. Round | 16/04/2022 | SV 19 Straelen | - | Alemannia Aachen | 0:1 | ||||
| 26. Round | 20/04/2022 | Alemannia Aachen | - | 1. FC Köln II | 1:1 | ||||
| 35. Round | 24/04/2022 | Alemannia Aachen | - | Wuppertaler SV | 1:2 | |
Germany