| 1. Round | 29/08/2021 | Hammer SpVg | - | TuS Erndtebrück | 4:0 | ||||
| 2. Round | 05/09/2021 | Preußen Münster II | - | Hammer SpVg | 4:2 | ||||
| 3. Round | 12/09/2021 | Hammer SpVg | - | SC Paderborn 07 II | 1:3 | ||||
| 5. Round | 26/09/2021 | Hammer SpVg | - | Westfalia Herne | 4:0 |  |
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| 6. Round | 03/10/2021 | Westfalia Rhynern | - | Hammer SpVg | 5:2 | ||||
| 10. Round | 31/10/2021 | 1. FC Kaan-Marienborn | - | Hammer SpVg | 3:0 | ||||
| 11. Round | 07/11/2021 | Hammer SpVg | - | Viktoria Clarholz | 4:3 | ||||
| 12. Round | 14/11/2021 | TuS Ennepetal | - | Hammer SpVg | 2:2 | |
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| 13. Round | 19/11/2021 | Hammer SpVg | - | SV Schermbeck | 0:2 | |
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| 19. Round | 13/03/2022 | SpVgg Vreden | - | Hammer SpVg | 1:0 | ||||
| 20. Round | 20/03/2022 | Hammer SpVg | - | FC Gütersloh | 0:0 | ||||
| 21. Round | 27/03/2022 | TuS Haltern | - | Hammer SpVg | 0:3 |
Germany