| 8. Round | 26/09/2010 | 1. FSV Mainz 05 II | - | Arminia Bielefeld II | 3:0 | ||||
| 10. Round | 17/10/2010 | 1. FSV Mainz 05 II | - | Fortuna Düsseldorf II | 1:5 | ||||
| 11. Round | 23/10/2010 | 1. FSV Mainz 05 II | - | Sportfreunde Lotte | 3:1 | ||||
| 12. Round | 30/10/2010 | FC Schalke 04 II | - | 1. FSV Mainz 05 II | 0:2 | ||||
| 13. Round | 06/11/2010 | 1. FSV Mainz 05 II | - | VfL Bochum II | 0:3 | ||||
| 26. Round | 03/04/2011 | 1. FSV Mainz 05 II | - | Borussia Dortmund II | 1:2 | ||||
| 27. Round | 09/04/2011 | Fortuna Düsseldorf II | - | 1. FSV Mainz 05 II | 2:5 | ||||
| 29. Round | 24/04/2011 | 1. FSV Mainz 05 II | - | FC Schalke 04 II | 3:0 | ||||
| 30. Round | 29/04/2011 | VfL Bochum II | - | 1. FSV Mainz 05 II | 4:2 |  |
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| 31. Round | 08/05/2011 | 1. FSV Mainz 05 II | - | SC Wiedenbrück | 0:3 | ||||
| 32. Round | 13/05/2011 | Bayer Leverkusen II | - | 1. FSV Mainz 05 II | 3:1 | ||||
| 34. Round | 28/05/2011 | SV 07 Elversberg | - | 1. FSV Mainz 05 II | 1:2 |
Germany