| 1. Round | 15/08/2021 | Hertha Zehlendorf [Youth B] | - | FC St. Pauli [Youth B] | 0:1 |  |
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| 2. Round | 22/08/2021 | FC St. Pauli [Youth B] | - | Hansa Rostock [Youth B] | 2:1 |  |
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| 3. Round | 28/08/2021 | Chemnitzer FC [Youth B] | - | FC St. Pauli [Youth B] | 1:0 | |
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| 4. Round | 11/09/2021 | FC St. Pauli [Youth B] | - | FC Carl Zeiss Jena [Youth B] | 4:0 | ||||
| 6. Round | 25/09/2021 | FC St. Pauli [Youth B] | - | 1. FC Union Berlin [Youth B] | 0:2 | ||||
| 7. Round | 02/10/2021 | Hannover 96 [Youth B] | - | FC St. Pauli [Youth B] | 0:0 | |
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| 8. Round | 09/10/2021 | FC St. Pauli [Youth B] | - | Dynamo Dresden [Youth B] | 3:1 | ||||
| 9. Round | 30/10/2021 | FC Viktoria 1889 Berlin [Youth B] | - | FC St. Pauli [Youth B] | 0:1 | |
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| 10. Round | 06/11/2021 | FC St. Pauli [Youth B] | - | Erzgebirge Aue [Youth B] | 5:0 | |
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| 14. Round | 26/02/2022 | Hertha BSC [Youth B] | - | FC St. Pauli [Youth B] | 2:0 | ||||
| 15. Round | 05/03/2022 | FC St. Pauli [Youth B] | - | VfL Wolfsburg [Youth B] | 1:1 | ||||
| 11. Round | 08/03/2022 | RB Leipzig [Youth B] | - | FC St. Pauli [Youth B] | 1:2 | ||||
| 16. Round | 05/04/2022 | Eintracht Braunschweig [Youth B] | - | FC St. Pauli [Youth B] | 0:2 |
Germany
Turkey