| 22. Round | 22/01/2022 | Alemannia Aachen | - | SV Lippstadt 08 | 3:0 | ||||
| 24. Round | 05/02/2022 | Alemannia Aachen | - | KFC Uerdingen 05 | 3:2 |  |
|||
| 25. Round | 12/02/2022 | SC Wiedenbrück | - | Alemannia Aachen | 1:1 |  |
|||
| 19. Round | 16/02/2022 | Alemannia Aachen | - | VfB Homberg | 2:0 | ||||
| 27. Round | 26/02/2022 | Alemannia Aachen | - | Bonner SC | 0:0 | |
|||
| 28. Round | 05/03/2022 | Bor. Mönchengladbach II | - | Alemannia Aachen | 3:2 | |
|||
| 29. Round | 12/03/2022 | Alemannia Aachen | - | Sportfreunde Lotte | 1:0 | |
|||
| 23. Round | 16/03/2022 | Rot-Weiß Oberhausen | - | Alemannia Aachen | 2:1 | ||||
| 30. Round | 19/03/2022 | FC Wegberg-Beeck | - | Alemannia Aachen | 0:2 | ||||
| 31. Round | 27/03/2022 | Alemannia Aachen | - | SV Rödinghausen | 0:1 | |
|||
| 26. Round | 20/04/2022 | Alemannia Aachen | - | 1. FC Köln II | 1:1 | |
|||
| 35. Round | 24/04/2022 | Alemannia Aachen | - | Wuppertaler SV | 1:2 | ||||
| 32. Round | 27/04/2022 | Rot Weiss Ahlen | - | Alemannia Aachen | 0:2 | ||||
| 36. Round | 30/04/2022 | Fortuna Köln | - | Alemannia Aachen | 0:0 | |
|||
| 37. Round | 06/05/2022 | Alemannia Aachen | - | Fortuna Düsseldorf II | 3:1 | ||||
| 38. Round | 14/05/2022 | VfB Homberg | - | Alemannia Aachen | 0:0 | |
Germany