| 2. Round | 29/08/2021 | SpVgg Sterkrade-Nord | - | SC Union Nettetal | 1:2 | ||||
| 3. Round | 05/09/2021 | SC Union Nettetal | - | Schwarz-Weiß Essen | 1:3 | ||||
| 4. Round | 12/09/2021 | FC Kray | - | SC Union Nettetal | 3:2 | ||||
| 6. Round | 26/09/2021 | TuRU Düsseldorf | - | SC Union Nettetal | 2:0 | ||||
| 7. Round | 01/10/2021 | SC Union Nettetal | - | Germania Ratingen 04/19 | 4:2 | ||||
| 8. Round | 10/10/2021 | 1. FC Monheim | - | SC Union Nettetal | 2:1 |  |
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| 9. Round | 16/10/2021 | SC Union Nettetal | - | 1. FC Mönchengladbach | 3:0 | ||||
| 10. Round | 24/10/2021 | FSV Duisburg | - | SC Union Nettetal | 1:2 | ||||
| 11. Round | 30/10/2021 | SC Union Nettetal | - | VfB 03 Hilden | 0:4 | ||||
| 12. Round | 07/11/2021 | SC Velbert | - | SC Union Nettetal | 1:1 | ||||
| 13. Round | 13/11/2021 | SC Union Nettetal | - | Sportfreunde Niederwenigern | 2:0 | ||||
| 14. Round | 28/11/2021 | TV Jahn Hiesfeld | - | SC Union Nettetal | 1:3 |  |
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| 15. Round | 04/12/2021 | SC Union Nettetal | - | SpVg Schonnebeck | 1:0 | ||||
| 16. Round | 11/12/2021 | Cronenberger SC | - | SC Union Nettetal | 2:1 | ||||
| 18. Round | 23/02/2022 | SC Union Nettetal | - | SC Düsseldorf-West | 1:4 | ||||
| 19. Round | 26/02/2022 | Sportfreunde Baumberg | - | SC Union Nettetal | 4:2 |
Germany