| 21. Round | 20/01/2018 | SV Wehen Wiesbaden | - | VfL Osnabrück | 5:1 |  |
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| 22. Round | 27/01/2018 | SpVgg Unterhaching | - | SV Wehen Wiesbaden | 0:1 | |
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| 23. Round | 02/02/2018 | SV Wehen Wiesbaden | - | Karlsruher SC | 1:1 | ||||
| 25. Round | 17/02/2018 | Fortuna Köln | - | SV Wehen Wiesbaden | 1:0 | ||||
| 26. Round | 24/02/2018 | SV Wehen Wiesbaden | - | Hallescher FC | 3:1 | ||||
| 28. Round | 06/03/2018 | SV Wehen Wiesbaden | - | Sportfreunde Lotte | 3:1 | ||||
| 29. Round | 10/03/2018 | SG Sonnenhof Großaspach | - | SV Wehen Wiesbaden | 1:3 | |
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| 30. Round | 16/03/2018 | SV Wehen Wiesbaden | - | Rot-Weiß Erfurt | 4:2 | |
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| 31. Round | 24/03/2018 | SV Meppen | - | SV Wehen Wiesbaden | 1:3 | |
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| 27. Round | 27/03/2018 | Chemnitzer FC | - | SV Wehen Wiesbaden | 1:4 | |
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| 32. Round | 31/03/2018 | SV Wehen Wiesbaden | - | Würzburger Kickers | 0:2 | ||||
| 33. Round | 07/04/2018 | Preußen Münster | - | SV Wehen Wiesbaden | 1:0 |  |
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| 35. Round | 21/04/2018 | Hansa Rostock | - | SV Wehen Wiesbaden | 2:0 | ||||
| 36. Round | 28/04/2018 | SV Wehen Wiesbaden | - | FSV Zwickau | 3:0 | ||||
| 37. Round | 05/05/2018 | SC Paderborn 07 | - | SV Wehen Wiesbaden | 3:1 | ||||
| 38. Round | 12/05/2018 | SV Wehen Wiesbaden | - | VfR Aalen | 2:0 | |
Germany