| 1. Round | 07/08/2021 | FC Carl Zeiss Jena II | - | Blau-Weiß Zorbau | 1:2 | ||||
| 16. Round | 31/08/2021 | FC Carl Zeiss Jena II | - | Rot-Weiß Erfurt | 1:2 | ||||
| 3. Round | 05/09/2021 | FC Einheit Rudolstadt | - | FC Carl Zeiss Jena II | 1:3 | ||||
| 8. Round | 25/09/2021 | FC Oberlausitz | - | FC Carl Zeiss Jena II | 0:3 | ||||
| 9. Round | 01/10/2021 | FC Carl Zeiss Jena II | - | SV 09 Arnstadt | 1:1 | ||||
| 12. Round | 31/10/2021 | Einheit Wernigerode | - | FC Carl Zeiss Jena II | 3:5 | ||||
| 14. Round | 20/11/2021 | VfB 1921 Krieschow | - | FC Carl Zeiss Jena II | 6:0 | ||||
| 28. Round | 14/05/2022 | SV 09 Arnstadt | - | FC Carl Zeiss Jena II | 4:1 | ||||
| 17. Round | 21/05/2022 | FC Grimma | - | FC Carl Zeiss Jena II | 3:0 | ||||
| 30. Round | 28/05/2022 | Inter Leipzig | - | FC Carl Zeiss Jena II | 4:0 | ||||
| 31. Round | 04/06/2022 | FC Carl Zeiss Jena II | - | Einheit Wernigerode | 0:1 | ||||
| 32. Round | 11/06/2022 | FC Carl Zeiss Jena II | - | FSV Budissa Bautzen | 4:2 | ||||
| 33. Round | 18/06/2022 | FC Carl Zeiss Jena II | - | VfB 1921 Krieschow | 2:6 |
Germany