| 8. Round | 09/10/2021 | FC St. Pauli [Youth B] | - | Dynamo Dresden [Youth B] | 3:1 | ||||
| 9. Round | 30/10/2021 | FC Viktoria 1889 Berlin [Youth B] | - | FC St. Pauli [Youth B] | 0:1 | ||||
| 10. Round | 06/11/2021 | FC St. Pauli [Youth B] | - | Erzgebirge Aue [Youth B] | 5:0 | ||||
| 14. Round | 26/02/2022 | Hertha BSC [Youth B] | - | FC St. Pauli [Youth B] | 2:0 | ||||
| 11. Round | 08/03/2022 | RB Leipzig [Youth B] | - | FC St. Pauli [Youth B] | 1:2 |  |
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| 13. Round | 26/03/2022 | FC St. Pauli [Youth B] | - | Energie Cottbus [Youth B] | 2:0 | |
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| 17. Round | 02/04/2022 | FC St. Pauli [Youth B] | - | Werder Bremen [Youth B] | 2:1 | ||||
| 16. Round | 05/04/2022 | Eintracht Braunschweig [Youth B] | - | FC St. Pauli [Youth B] | 0:2 | ||||
| 18. Round | 09/04/2022 | Holstein Kiel [Youth B] | - | FC St. Pauli [Youth B] | 0:1 | ||||
| 19. Round | 24/04/2022 | FC St. Pauli [Youth B] | - | Hamburger SV [Youth B] | 1:3 |
Germany