| 7. Round | 20/11/2021 | Fortuna Köln [Youth] | - | Preußen Münster [Youth] | 1:4 | ||||
| 8. Round | 28/11/2021 | Preußen Münster [Youth] | - | MSV Duisburg [Youth] | 2:0 | ||||
| 9. Round | 05/12/2021 | Arminia Bielefeld [Youth] | - | Preußen Münster [Youth] | 0:1 | ||||
| 11. Round | 12/02/2022 | 1. FC Köln [Youth] | - | Preußen Münster [Youth] | 0:2 | ||||
| 12. Round | 20/02/2022 | Preußen Münster [Youth] | - | Fortuna Düsseldorf [Youth] | 1:3 | ||||
| 13. Round | 05/03/2022 | Alemannia Aachen [Youth] | - | Preußen Münster [Youth] | 0:6 | ||||
| 15. Round | 09/04/2022 | Wuppertaler SV [Youth] | - | Preußen Münster [Youth] | 0:3 | ||||
| 16. Round | 23/04/2022 | Preußen Münster [Youth] | - | Borussia Dortmund [Youth] | 1:5 | ||||
| 17. Round | 30/04/2022 | Viktoria Köln [Youth] | - | Preußen Münster [Youth] | 5:3 |
Germany