| 14. Round | 21/02/1981 | FC Vorwärts Frankfurt/Oder | - | FC Karl-Marx-Stadt | 4:1 | ||||
| 15. Round | 28/02/1981 | FC Karl-Marx-Stadt | - | 1. FC Magdeburg | 1:1 |  |
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| 16. Round | 07/03/1981 | BSG Wismut Aue | - | FC Karl-Marx-Stadt | 0:1 | ||||
| 17. Round | 14/03/1981 | FC Karl-Marx-Stadt | - | Rot-Weiß Erfurt | 1:1 | ||||
| 18. Round | 21/03/1981 | Dynamo Dresden | - | FC Karl-Marx-Stadt | 2:0 | ||||
| 23. Round | 09/05/1981 | FC Carl Zeiss Jena | - | FC Karl-Marx-Stadt | 5:0 | ||||
| 24. Round | 16/05/1981 | FC Karl-Marx-Stadt | - | HFC Chemie | 2:2 | ||||
| 25. Round | 23/05/1981 | BSG Sachsenring Zwickau | - | FC Karl-Marx-Stadt | 1:0 |  |
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| 26. Round | 30/05/1981 | FC Karl-Marx-Stadt | - | 1. FC Lokomotive Leipzig | 6:1 | |
Germany