| 5. Round | 03/10/2021 | SV Meppen [Women] | - | RB Leipzig [Women] | 5:0 |  |
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| 6. Round | 10/10/2021 | RB Leipzig [Women] | - | SG 99 Andernach [Women] | 0:1 | ||||
| 7. Round | 17/10/2021 | Borussia Bocholt [Women] | - | RB Leipzig [Women] | 1:9 | ||||
| 11. Round | 13/02/2022 | SV Henstedt-Ulzburg [Women] | - | RB Leipzig [Women] | 2:3 | ||||
| 14. Round | 27/02/2022 | RB Leipzig [Women] | - | VfL Wolfsburg II [Women] | 0:0 | ||||
| 15. Round | 06/03/2022 | 1899 Hoffenheim II [Women] | - | RB Leipzig [Women] | 0:3 | ||||
| 16. Round | 13/03/2022 | RB Leipzig [Women] | - | Bayern München II [Women] | 2:3 | ||||
| 25. Round | 22/05/2022 | RB Leipzig [Women] | - | FSV Gütersloh 2009 [Women] | 6:1 |
Germany