| 21. Round | 15/01/2022 | VfL Osnabrück | - | 1. FC Saarbrücken | 2:1 | ||||
| 22. Round | 23/01/2022 | MSV Duisburg | - | 1. FC Saarbrücken | 3:4 |  |
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| 23. Round | 26/01/2022 | 1. FC Saarbrücken | - | Borussia Dortmund II | 2:0 | ||||
| 24. Round | 29/01/2022 | 1. FC Magdeburg | - | 1. FC Saarbrücken | 2:1 | ||||
| 25. Round | 07/02/2022 | 1. FC Saarbrücken | - | Würzburger Kickers | 2:1 | ||||
| 26. Round | 13/02/2022 | SV Wehen Wiesbaden | - | 1. FC Saarbrücken | 1:0 | ||||
| 27. Round | 19/02/2022 | 1. FC Saarbrücken | - | Viktoria Köln | 0:1 | ||||
| 29. Round | 06/03/2022 | 1. FC Saarbrücken | - | SV Meppen | 1:0 | ||||
| 30. Round | 12/03/2022 | Eintracht Braunschweig | - | 1. FC Saarbrücken | 0:2 | ||||
| 33. Round | 09/04/2022 | 1. FC Saarbrücken | - | Waldhof Mannheim | 0:0 | ||||
| 34. Round | 17/04/2022 | 1. FC Kaiserslautern | - | 1. FC Saarbrücken | 3:1 | ||||
| 35. Round | 23/04/2022 | 1. FC Saarbrücken | - | SC Verl | 1:2 | ||||
| 36. Round | 29/04/2022 | FC Viktoria 1889 Berlin | - | 1. FC Saarbrücken | 2:1 | ||||
| 38. Round | 14/05/2022 | SC Freiburg II | - | 1. FC Saarbrücken | 1:1 |
Germany