| 2. Round | 04/09/2021 | Eintracht Braunschweig [Youth B] | - | Werder Bremen [Youth B] | 2:4 | ||||
| 4. Round | 11/09/2021 | Werder Bremen [Youth B] | - | Holstein Kiel [Youth B] | 6:2 | ||||
| 7. Round | 02/10/2021 | Hansa Rostock [Youth B] | - | Werder Bremen [Youth B] | 2:0 | ||||
| 8. Round | 09/10/2021 | Werder Bremen [Youth B] | - | Chemnitzer FC [Youth B] | 2:3 | ||||
| 1. Round | 13/10/2021 | Werder Bremen [Youth B] | - | VfL Wolfsburg [Youth B] | 0:3 | ||||
| 9. Round | 30/10/2021 | FC Carl Zeiss Jena [Youth B] | - | Werder Bremen [Youth B] | 1:2 | ||||
| 10. Round | 06/11/2021 | Werder Bremen [Youth B] | - | Hallescher FC [Youth B] | 5:0 | ||||
| 11. Round | 21/11/2021 | 1. FC Union Berlin [Youth B] | - | Werder Bremen [Youth B] | 1:1 |  |
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| 12. Round | 27/11/2021 | Werder Bremen [Youth B] | - | Hannover 96 [Youth B] | 4:3 | ||||
| 13. Round | 19/02/2022 | Dynamo Dresden [Youth B] | - | Werder Bremen [Youth B] | 0:4 | ||||
| 15. Round | 05/03/2022 | Erzgebirge Aue [Youth B] | - | Werder Bremen [Youth B] | 0:2 | |
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| 18. Round | 09/04/2022 | Werder Bremen [Youth B] | - | Energie Cottbus [Youth B] | 5:5 | ||||
| 19. Round | 23/04/2022 | Hertha BSC [Youth B] | - | Werder Bremen [Youth B] | 1:1 |
Poland