| 1. Round | 15/08/2021 | FSV Frankfurt [Youth B] | - | Stuttgarter Kickers [Youth B] | 2:1 | ||||
| 3. Round | 24/10/2021 | FSV Frankfurt [Youth B] | - | SpVgg Greuther Fürth [Youth B] | 1:2 | ||||
| 11. Round | 13/11/2021 | FSV Frankfurt [Youth B] | - | TSV 1860 München [Youth B] | 2:1 | ||||
| 12. Round | 27/11/2021 | 1899 Hoffenheim [Youth B] | - | FSV Frankfurt [Youth B] | 1:0 | ||||
| 13. Round | 05/12/2021 | FSV Frankfurt [Youth B] | - | Karlsruher SC [Youth B] | 3:2 |  |
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| 14. Round | 11/12/2021 | SV Wehen Wiesbaden [Youth B] | - | FSV Frankfurt [Youth B] | 2:1 | |
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| 15. Round | 20/02/2022 | FSV Frankfurt [Youth B] | - | SV 07 Elversberg [Youth B] | 2:0 | ||||
| 16. Round | 27/02/2022 | VfB Stuttgart [Youth B] | - | FSV Frankfurt [Youth B] | 3:0 | ||||
| 17. Round | 06/03/2022 | FSV Frankfurt [Youth B] | - | 1. FSV Mainz 05 [Youth B] | 1:2 | ||||
| 20. Round | 09/04/2022 | FSV Frankfurt [Youth B] | - | 1. FC Nürnberg [Youth B] | 0:3 | ||||
| 21. Round | 23/04/2022 | Bayern München [Youth B] | - | FSV Frankfurt [Youth B] | 3:2 | |
Germany