| 1. Round | 22/08/2021 | 1. FC Kleve | - | TSV Meerbusch | 2:1 |  |
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| 3. Round | 05/09/2021 | TSV Meerbusch | - | 1. FC Bocholt | 1:7 | |
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| 4. Round | 10/09/2021 | SSVg Velbert | - | TSV Meerbusch | 2:1 | ||||
| 6. Round | 26/09/2021 | SpVgg Sterkrade-Nord | - | TSV Meerbusch | 2:4 | ||||
| 8. Round | 10/10/2021 | FC Kray | - | TSV Meerbusch | 0:4 | ||||
| 9. Round | 17/10/2021 | TSV Meerbusch | - | DJK Teutonia St. Tönis | 2:1 | ||||
| 10. Round | 24/10/2021 | TuRU Düsseldorf | - | TSV Meerbusch | 0:1 | ||||
| 13. Round | 14/11/2021 | TSV Meerbusch | - | 1. FC Mönchengladbach | 5:2 | ||||
| 14. Round | 28/11/2021 | FSV Duisburg | - | TSV Meerbusch | 1:1 | ||||
| 15. Round | 02/12/2021 | TSV Meerbusch | - | VfB 03 Hilden | 0:5 | ||||
| 17. Round | 18/12/2021 | TSV Meerbusch | - | Sportfreunde Niederwenigern | 3:0 | ||||
| 18. Round | 20/02/2022 | TV Jahn Hiesfeld | - | TSV Meerbusch | 4:0 | ||||
| 19. Round | 27/02/2022 | TSV Meerbusch | - | SpVg Schonnebeck | 0:3 | ||||
| 20. Round | 06/03/2022 | Cronenberger SC | - | TSV Meerbusch | 4:1 | ||||
| 21. Round | 13/03/2022 | TSV Meerbusch | - | SC Union Nettetal | 3:3 |  |
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| 22. Round | 20/03/2022 | SC Düsseldorf-West | - | TSV Meerbusch | 0:0 | ||||
| 23. Round | 27/03/2022 | TSV Meerbusch | - | Sportfreunde Baumberg | 1:6 |
Germany