| 1. Round | 24/07/2021 | Hallescher FC | - | SV Meppen | 3:1 |  |
|||
| 2. Round | 01/08/2021 | Türkgücü München | - | Hallescher FC | annull. | ||||
| 3. Round | 16/08/2021 | Hallescher FC | - | Eintracht Braunschweig | 0:2 | ||||
| 4. Round | 20/08/2021 | FC Viktoria 1889 Berlin | - | Hallescher FC | 0:1 | |
 |
||
| 5. Round | 24/08/2021 | Hallescher FC | - | 1. FC Kaiserslautern | 1:0 | ||||
| 6. Round | 27/08/2021 | Hallescher FC | - | SC Verl | 4:4 | ||||
| 8. Round | 12/09/2021 | Hallescher FC | - | TSV 1860 München | 1:1 |  |
|||
| 10. Round | 24/09/2021 | Hallescher FC | - | 1. FC Magdeburg | 3:2 | |
|||
| 11. Round | 02/10/2021 | SC Freiburg II | - | Hallescher FC | 1:1 | ||||
| 12. Round | 16/10/2021 | Hallescher FC | - | 1. FC Saarbrücken | 2:3 | |
|||
| 13. Round | 22/10/2021 | VfL Osnabrück | - | Hallescher FC | 0:0 | ||||
| 14. Round | 30/10/2021 | Hallescher FC | - | MSV Duisburg | 2:1 | |
|||
| 15. Round | 06/11/2021 | TSV Havelse | - | Hallescher FC | 2:1 | ||||
| 16. Round | 20/11/2021 | Hallescher FC | - | Borussia Dortmund II | 1:2 | |
|||
| 18. Round | 04/12/2021 | Hallescher FC | - | Würzburger Kickers | 0:0 | ||||
| 19. Round | 13/12/2021 | SV Wehen Wiesbaden | - | Hallescher FC | 2:1 | ||||
| 20. Round | 18/12/2021 | SV Meppen | - | Hallescher FC | 4:1 | |
Germany