| 1. Round | 03/08/2010 | SSV Ulm 1846 | - | Karlsruher SC II | annull. | ||||
| 2. Round | 12/08/2010 | Karlsruher SC II | - | SC Freiburg II | 1:1 | ||||
| 14. Round | 30/10/2010 | 1. FC Nürnberg II | - | Karlsruher SC II | 1:2 | ||||
| 15. Round | 05/11/2010 | Karlsruher SC II | - | 1899 Hoffenheim II | 1:0 | ||||
| 16. Round | 12/11/2010 | TSV 1860 München II | - | Karlsruher SC II | 1:0 | ||||
| 17. Round | 20/11/2010 | Karlsruher SC II | - | SV Wehen Wiesbaden II | 1:0 | ||||
| 19. Round | 04/12/2010 | Karlsruher SC II | - | SSV Ulm 1846 | annull. | ||||
| 30. Round | 29/04/2011 | Stuttgarter Kickers | - | Karlsruher SC II | 2:2 |  |
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| 31. Round | 08/05/2011 | Karlsruher SC II | - | 1. FC Nürnberg II | 1:1 | ||||
| 32. Round | 13/05/2011 | 1899 Hoffenheim II | - | Karlsruher SC II | 1:5 |  |
Germany