| 12. Round | 20/11/1999 | 1. FSV Mainz 05 | - | SpVgg Greuther Fürth | 1:0 |  |
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| 14. Round | 05/12/1999 | 1. FSV Mainz 05 | - | VfL Bochum | 0:1 | |
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| 18. Round | 12/02/2000 | Kickers Offenbach | - | 1. FSV Mainz 05 | 2:2 | |
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| 22. Round | 10/03/2000 | 1. FSV Mainz 05 | - | Chemnitzer FC | 5:0 |  |
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| 23. Round | 17/03/2000 | Hannover 96 | - | 1. FSV Mainz 05 | 2:1 | |
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| 24. Round | 26/03/2000 | 1. FSV Mainz 05 | - | Karlsruher SC | 2:2 | ||||
| 25. Round | 02/04/2000 | Alemannia Aachen | - | 1. FSV Mainz 05 | 1:0 | ||||
| 26. Round | 07/04/2000 | 1. FSV Mainz 05 | - | FC St. Pauli | 1:1 | ||||
| 27. Round | 16/04/2000 | 1. FC Köln | - | 1. FSV Mainz 05 | 1:0 | ||||
| 28. Round | 20/04/2000 | 1. FSV Mainz 05 | - | Rot-Weiß Oberhausen | 1:1 | |
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| 30. Round | 07/05/2000 | 1. FSV Mainz 05 | - | Stuttgarter Kickers | 2:0 | ||||
| 31. Round | 15/05/2000 | VfL Bochum | - | 1. FSV Mainz 05 | 0:1 | ||||
| 32. Round | 18/05/2000 | 1. FSV Mainz 05 | - | TeBe Berlin | 2:1 | ||||
| 33. Round | 21/05/2000 | Bor. Mönchengladbach | - | 1. FSV Mainz 05 | 6:1 | ||||
| 34. Round | 26/05/2000 | 1. FSV Mainz 05 | - | Waldhof Mannheim | 2:0 |
Germany