| 1. Round | 17/09/2015 | SV Zweckel | - | SC Paderborn 07 II | 0:0 | ||||
| 9. Round | 10/10/2015 | TSG Sprockhövel | - | SC Paderborn 07 II | 2:1 | ||||
| 13. Round | 14/11/2015 | TSV Marl-Hüls | - | SC Paderborn 07 II | 3:0 | ||||
| 14. Round | 29/11/2015 | SC Paderborn 07 II | - | TuS Ennepetal | 1:1 | ||||
| 15. Round | 05/12/2015 | Hammer SpVg | - | SC Paderborn 07 II | 2:2 | ||||
| 18. Round | 14/02/2016 | SC Paderborn 07 II | - | SV Zweckel | 2:3 | ||||
| 19. Round | 21/02/2016 | ASC 09 Dortmund | - | SC Paderborn 07 II | 2:1 | ||||
| 20. Round | 27/02/2016 | SC Paderborn 07 II | - | Roland Beckum | 3:0 | ||||
| 21. Round | 06/03/2016 | SV Schermbeck 1912 | - | SC Paderborn 07 II | 0:0 | ||||
| 22. Round | 13/03/2016 | SC Paderborn 07 II | - | SuS Stadtlohn | 2:2 | ||||
| 24. Round | 24/03/2016 | SC Paderborn 07 II | - | Westfalia Rhynern | 1:2 | ||||
| 25. Round | 28/03/2016 | SuS Neuenkirchen | - | SC Paderborn 07 II | 2:3 | ||||
| 27. Round | 10/04/2016 | Arminia Bielefeld II | - | SC Paderborn 07 II | 0:0 | ||||
| 30. Round | 30/04/2016 | SC Paderborn 07 II | - | TSV Marl-Hüls | 2:3 | ||||
| 33. Round | 22/05/2016 | FCE Rheine | - | SC Paderborn 07 II | 5:2 | ||||
| 34. Round | 29/05/2016 | SC Paderborn 07 II | - | SV Lippstadt 08 | 2:0 |  |
Germany