| 1. Round | 17/09/2015 | SV Zweckel | - | SC Paderborn 07 II | 0:0 |  |
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| 8. Round | 04/10/2015 | SC Paderborn 07 II | - | SuS Neuenkirchen | 3:1 | ||||
| 9. Round | 10/10/2015 | TSG Sprockhövel | - | SC Paderborn 07 II | 2:1 | ||||
| 10. Round | 17/10/2015 | SC Paderborn 07 II | - | Arminia Bielefeld II | 3:2 | ||||
| 11. Round | 25/10/2015 | FC Gütersloh 2000 | - | SC Paderborn 07 II | 0:2 | ||||
| 12. Round | 08/11/2015 | SC Paderborn 07 II | - | Sportfreunde Siegen | 1:1 | ||||
| 13. Round | 14/11/2015 | TSV Marl-Hüls | - | SC Paderborn 07 II | 3:0 | ||||
| 14. Round | 29/11/2015 | SC Paderborn 07 II | - | TuS Ennepetal | 1:1 | ||||
| 15. Round | 05/12/2015 | Hammer SpVg | - | SC Paderborn 07 II | 2:2 |  |
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| 16. Round | 13/12/2015 | SC Paderborn 07 II | - | FCE Rheine | 2:2 | ||||
| 17. Round | 21/12/2015 | SV Lippstadt 08 | - | SC Paderborn 07 II | 1:0 | ||||
| 18. Round | 14/02/2016 | SC Paderborn 07 II | - | SV Zweckel | 2:3 | |
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| 19. Round | 21/02/2016 | ASC 09 Dortmund | - | SC Paderborn 07 II | 2:1 | |
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| 27. Round | 10/04/2016 | Arminia Bielefeld II | - | SC Paderborn 07 II | 0:0 | ||||
| 31. Round | 08/05/2016 | TuS Ennepetal | - | SC Paderborn 07 II | 1:2 | ||||
| 32. Round | 15/05/2016 | SC Paderborn 07 II | - | Hammer SpVg | 1:2 | |
Germany