| 1. Round | 14/08/2021 | FC St. Pauli [Youth] | - | Holstein Kiel [Youth] | 3:6 |  |
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| 2. Round | 21/08/2021 | RB Leipzig [Youth] | - | FC St. Pauli [Youth] | 2:2 | |
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| 3. Round | 11/09/2021 | FC St. Pauli [Youth] | - | Chemnitzer FC [Youth] | 3:0 | ||||
| 4. Round | 17/09/2021 | Eimsbütteler TV [Youth] | - | FC St. Pauli [Youth] | 1:1 | ||||
| 5. Round | 25/09/2021 | FC St. Pauli [Youth] | - | Dynamo Dresden [Youth] | 0:1 | ||||
| 6. Round | 02/10/2021 | FC Viktoria 1889 Berlin [Youth] | - | FC St. Pauli [Youth] | 3:0 | ||||
| 7. Round | 16/10/2021 | FC St. Pauli [Youth] | - | Hallescher FC [Youth] | 3:2 | |
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| 8. Round | 23/10/2021 | VfL Wolfsburg [Youth] | - | FC St. Pauli [Youth] | 2:2 | ||||
| 9. Round | 30/10/2021 | FC St. Pauli [Youth] | - | Werder Bremen [Youth] | 0:1 | ||||
| 12. Round | 05/02/2022 | 1. FC Union Berlin [Youth] | - | FC St. Pauli [Youth] | 2:1 | ||||
| 11. Round | 12/02/2022 | FC St. Pauli [Youth] | - | 1. FC Magdeburg [Youth] | 2:1 | |
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| 14. Round | 27/02/2022 | Hansa Rostock [Youth] | - | FC St. Pauli [Youth] | 5:1 |
Germany