| 1. Round | 14/08/2021 | Arminia Ludwigshafen | - | FV 07 Diefflen | 5:1 |  |
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| 2. Round | 21/08/2021 | FV 07 Diefflen | - | SV 07 Elversberg II | 1:3 | ||||
| 3. Round | 24/08/2021 | SV Röchling Völklingen | - | FV 07 Diefflen | 1:3 | ||||
| 4. Round | 28/08/2021 | FV 07 Diefflen | - | FV Eppelborn | 2:0 |  |
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| 5. Round | 04/09/2021 | TuS Mechtersheim | - | FV 07 Diefflen | 0:5 | ||||
| 6. Round | 11/09/2021 | FV 07 Diefflen | - | TSG Pfeddersheim | 0:1 | ||||
| 7. Round | 18/09/2021 | FV Dudenhofen | - | FV 07 Diefflen | 4:0 | ||||
| 8. Round | 22/09/2021 | FV 07 Diefflen | - | FSV Jägersburg | 2:1 | ||||
| 9. Round | 26/09/2021 | FC Speyer 09 | - | FV 07 Diefflen | 3:4 | ||||
| 10. Round | 02/10/2021 | FC Hertha Wiesbach | - | FV 07 Diefflen | 1:2 | ||||
| 11. Round | 09/10/2021 | FV 07 Diefflen | - | Wormatia Worms | 1:4 | ||||
| 12. Round | 16/10/2021 | FV 07 Diefflen | - | Arminia Ludwigshafen | 3:3 | ||||
| 14. Round | 27/10/2021 | FV 07 Diefflen | - | SV Röchling Völklingen | 1:1 | ||||
| 15. Round | 30/10/2021 | FV Eppelborn | - | FV 07 Diefflen | 3:1 | ||||
| 21. Round | 26/02/2022 | FV 07 Diefflen | - | FC Hertha Wiesbach | 2:0 | ||||
| 22. Round | 05/03/2022 | Wormatia Worms | - | FV 07 Diefflen | 3:1 |  |
Germany