| 1. Round | 13/08/2021 | 1. FC Düren | - | Viktoria Arnoldsweiler | 4:2 | ||||
| 3. Round | 22/08/2021 | 1. FC Düren | - | Spvg Wesseling-Urfeld | 7:0 | ||||
| 5. Round | 05/09/2021 | 1. FC Düren | - | BC Viktoria Glesch-Paffendorf | 3:0 | ||||
| 6. Round | 12/09/2021 | FC Pesch 1956 | - | 1. FC Düren | 1:2 | ||||
| 8. Round | 25/09/2021 | SV Deutz 05 | - | 1. FC Düren | 0:4 | ||||
| 10. Round | 10/10/2021 | 1. FC Düren | - | Fortuna Köln II | 4:0 | ||||
| 11. Round | 17/10/2021 | FC Hennef 05 | - | 1. FC Düren | 0:2 | ||||
| 14. Round | 07/11/2021 | 1. FC Düren | - | Borussia Freialdenhoven | 2:0 | ||||
| 16. Round | 28/11/2021 | 1. FC Düren | - | SV Bergisch Gladbach 09 | 1:0 | ||||
| 17. Round | 05/12/2021 | SV 1914 Eilendorf | - | 1. FC Düren | 0:2 | ||||
| 20. Round | 06/03/2022 | Spvg Wesseling-Urfeld | - | 1. FC Düren | 0:6 |  |
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| 21. Round | 13/03/2022 | 1. FC Düren | - | SV Breinig | 3:0 | ||||
| 27. Round | 24/04/2022 | Fortuna Köln II | - | 1. FC Düren | 1:7 | ||||
| 32. Round | 29/05/2022 | 1. FC Düren | - | Blau-Weiß Friesdorf | 4:0 | ||||
| 33. Round | 06/06/2022 | SV Bergisch Gladbach 09 | - | 1. FC Düren | 3:3 | ||||
| 34. Round | 12/06/2022 | 1. FC Düren | - | SV 1914 Eilendorf | 3:0 |
Germany